How Can Disruption of Transcription Factor Function Lead to Development of Leukemia?

Introduction Hematopoiesis is the process of continuous production of gillyflower carrels during the wide life span of an individual; it depends on a image of r ar pluripotential cell, hematopoietic stem cell (HSC), whose abundance is tightly regulated by several processes, including self-renewal, proliferation, personal credit line specification, differentiation, maturation and apoptosis. haematological malignancy arises when the normal regulatory processes of haemopoiesis lose its control, accumulating deviant blood cells in bone marrow and circulation (Downing and Shannon, 2002). Leukemias are a type of hematological disease characterized by clonal magnification of white cells which undergone genetic alterations. The detailed chemical mechanism of leukemogenesis remains more much than not unknown; all the same it is believed that the malignancy development depends on the conspiracy of genetic cathode-ray oscilloscope and environmental factors. Leukemia can be sort out into foursome types, acute and chronic leukemias, which are further subdivided into lymphoid or myeloid lineages. Genetic Mutations in Leukemia Chromosomal Abnormalities, make-up of oncogene and Dysregulation of Tumor Suppressor Gene As mentioned, malignant faulting occurs as a result of the accumulation of genetic mutations in cellular genes.

These genetic mutations include chromosomal translocation, inversion, deletion, gene enlargement and heading mutations. The genes that are bear on in the development of crab dirt ball can be divided broadly into two groups, oncogene and tumor-suppressor gene. Duri ng normal hematopoiesis, proliferation of bl! ood cells depends on a equilibrise amid the litigate of proto-oncogenes and tumor suppressor genes. In malignant cell, this balance is pale leading to uncontrolled cell division. Oncogene is derived from proto-oncogene which undergone gain-of-function mutation. Proto-oncogenes are involved in a variety of important cellular processes, often in the signal transduction pathway for gene activation....If you motive to look at a full essay, order it on our website: OrderCustomPaper.com

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